Identification of O-mannosylated Virulence Factors in Ustilago maydis

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Identification of O-mannosylated Virulence Factors in Ustilago maydis

The O-mannosyltransferase Pmt4 has emerged as crucial for fungal virulence in the animal pathogens Candida albicans or Cryptococcus neoformans as well as in the phytopathogenic fungus Ustilago maydis. Pmt4 O-mannosylates specific target proteins at the Endoplasmic Reticulum. Therefore a deficient O-mannosylation of these target proteins must be responsible for the loss of pathogenicity in pmt4 ...

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ژورنال

عنوان ژورنال: PLoS Pathogens

سال: 2012

ISSN: 1553-7374

DOI: 10.1371/journal.ppat.1002563